Low-dose splenic irradiation in symptomatic congestive splenomegaly: report of five cases with literature data
1 Department of Radiation Oncology, Hannover Medical School, 30625 Hannover, Germany
2 Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
Radiation Oncology 2014, 9:86 doi:10.1186/1748-717X-9-86Published: 27 March 2014
To show effectiveness of low-dose splenic irradiation in symptomatic congestive splenomegaly.
Five patients were referred to our department for symptomatic congestive splenomegaly within three years. Primary diseases were autoimmune hepatitis with liver cirrhosis (n = 2), cystic fibrosis (n = 1), granulomatous liver disease (n = 1) and Werlhof disease with liver cirrhosis (n = 1). Mean age was 54 years (range: 36–67). Patients received splenic irradiation with a total dose of 3 Gy (single dose: 0.5 Gy). One patient was re-irradiated after long-term failure with the same treatment schedule.
In four patients long term relief of splenic pain could be observed during the follow-up time of median 20 (range: 2–36) months. Four patients showed haematological response after irradiation with an increase of erythrocytes, leucocytes and/or platelets. A slightly decrease in spleen size was found in two patients.
Low-dose splenic irradiation in symptomatic congestive splenomegaly is feasible and perhaps as effective as in lympho-and myeloproliferative malignancies regarding pain relief and haematological response.