Patterns of radiotherapy practice for biliary tract cancer in Japan: results of the Japanese radiation oncology study group (JROSG) survey
1 Department of Radiation Oncology, Osaka University Graduate School of Medicine, 2-2 (D-10) Yamadaoka, Suita, Osaka, 565-0871, Japan
2 Department of Radiology, Iwate Medical University, 19-1 Uchimaru, Morioka, Iwate, 020-8505, Japan
3 Department of Radiology, University of Yamanashi, 1110, Shimogato Chuo, Yamanashi, 409-3898, Japan
4 Department of Radiation Oncology, Shimane University, 1060 Nishikawatsu-cho, Matsue-shi, Shimane, 690-8504, Japan
5 Present affiliation: Department of Radiation Oncology, Tottori Prefectural Central Hospital, 730 Etsu, Tottori-shi, Tottori, 680-0901, Japan
6 Department of Radiology, Nihon University School of Medicine, 30-1, Ohyaguchi-Kamimachi, Itabashi-ku, Tokyo, 173-8610, Japan
7 Department of Radiology, Tokyo Medical University, 6-1-1, Shinjuku, Shinjuju-ku, Tokyo, 160-8402, Japan
8 Department of Radiation Oncology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8521, Japan
9 Division of Radiation Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi Town, Shizuoka, 411-8777, Japan
10 Department of Radiology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu city, Shizuoka, 431-3192, Japan
11 Department of Radiology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chiba, 260-8677, Japan
12 Department of Radiation Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan
13 Department of Radiation Oncology, Tokyo Metropolitan Komagome Hospital, 18-22, Honkomagome 3chome, Bunkyo-ku, Tokyo, 113-8677, Japan
14 Department of Radiology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan
15 Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho-cho, Mizuho-ku Nagoya, Aichi, 467-8601, Japan
16 Department of Radiology, Kyoto Prefectural University of Medicine, Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan
17 Department of Radiology, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan
18 Department of Radiation Oncology, Yamagata University, 2-2-2 Iida-Nishi, Yamagata-shi, Yamagata, 990-9585, Japan
19 Department of Radiation Oncology, Kinki University Faculty of Medicine, 377-2, Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan
Radiation Oncology 2013, 8:76 doi:10.1186/1748-717X-8-76Published: 1 April 2013
The patterns of radiotherapy (RT) practice for biliary tract cancer (BTC) in Japan are not clearly established.
A questionnaire-based national survey of RT used for BTC treatment between 2000 and 2011 was conducted by the Japanese Radiation Oncology Study Group. Detailed information was collected for 555 patients from 31 radiation oncology institutions.
The median age of the patients was 69 years old (range, 33–90) and 81% had a good performance status (0–1). Regarding RT treatment, 78% of the patients were treated with external beam RT (EBRT) alone, 17% received intraluminal brachytherapy, and 5% were treated with intraoperative RT. There was no significant difference in the choice of treatment modality among the BTC subsites. Many patients with EBRT were treated with a total dose of 50 or 50.4 Gy (~40%) and only 13% received a total dose ≥60 Gy, even though most institutions (90%) were using CT-based treatment planning. The treatment field consisted of the primary tumor (bed) only in 75% of the patients. Chemotherapy was used for 260 patients (47%) and was most often administered during RT (64%, 167/260), followed by after RT (63%, 163/260). Gemcitabine was the most frequently used drug for chemotherapy.
This study established the general patterns of RT practice for BTC in Japan. Further surveys and comparisons with results from other countries are needed for development and optimization of RT for patients with BTC in Japan.