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Open Access Research

Paclitaxel and cisplatin combined with intensity-modulated radiotherapy for upper esophageal carcinoma

Lingli Tu, Lan Sun, Yong Xu, Yongsheng Wang, Lin Zhou, Yongmei Liu, Jiang Zhu, Feng Peng, Yuquan Wei and Youling Gong*

Author Affiliations

Department of Thoracic Oncology and State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China

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Radiation Oncology 2013, 8:75  doi:10.1186/1748-717X-8-75

Published: 27 March 2013

Abstract

Purpose

This study was conducted to evaluate the effectiveness and safety of intensity-modulated radiotherapy (IMRT) and concurrent paclitaxel plus cisplatin (TP regimen) for upper esophageal carcinoma.

Methods

36 patients of upper esophageal carcinoma were retrospectively analyzed. Patients were treated with IMRT (median 60 Gy) combined with concurrent TP regimen chemotherapy. The Kaplan-Meier analysis was performed in statistical analysis. Toxicities were recorded according to the NCI CTC version 3.0.

Results

36 patients aged 43–73 years (median 57 years). The median follow-up period was 14.0 months. The 1-year and 2-year survival rates were 83.3% and 42.8% respectively. The median progression-free survival (PFS) time and overall survival (OS) time were 12.0 (95% CI: 7.8–16.2 months) and 18.0 months (95% CI: 9.9–26.1 months), respectively. Grade 3 neutropenia, radiation-induced esophagitis and radiodermatitis were observed in 5 (13.9%), 3 (8.3%) and 8 (22.2%) patients respectively. There were two treatment-related deaths due to esophageal perforation and hemorrhea.

Conclusions

For those patients with upper esophageal carcinoma, IMRT combined with concurrent TP regimen chemotherapy was an effective treatment. However, more attention should be paid to the occurrence of perforation and hemorrhea.

Keywords:
Upper esophageal carcinoma; Paclitaxel; Cisplatin; Intensity-modulated radiotherapy