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Open Access Case report

Radiotherapy of primary cutaneous follicle center lymphoma: case report and review of literature

Romana Ceovic1*, Ivana Jovanovic2, Kresimir Kostovic1, Jaka Rados1, Snjezana Dotlic3, Ivo Radman4, Sandra Marinovic Kulisic1 and Davorin Loncaric1

Author Affiliations

1 Department of Dermatology and Venereology, University Hospital Center Zagreb and School of Medicine, Zagreb, Croatia

2 Department of Dermatology and Venereology, Dr. Josip Benčević General Hospital, Slavonski Brod, Croatia

3 Department of Pathology, University Hospital Center Zagreb and School of Medicine, Zagreb, Croatia

4 Department of Hematology, University Hospital Center Zagreb and School of Medicine Zagreb, Zagreb, Croatia

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Radiation Oncology 2013, 8:147  doi:10.1186/1748-717X-8-147

Published: 20 June 2013

Abstract

Primary cutaneous follicle center lymphoma is an indolent primary cutaneous B-cell lymphoma originating from the follicle center cells, composed of a combination of centrocytes (small and large cleaved cells) and centroblasts (large noncleaved cells) with a follicular, follicular/diffuse, or diffuse growth pattern. Lesions are mostly located on the head, neck and trunk. A case is presented of a 56-year-old male patient with primary cutaneous follicle center lymphoma, with lesions involving the skin of the back, shoulders, presternal area and right forearm. As the patient presented a disseminated cutaneous form of the disease that involved several anatomical regions, complete work-up was followed by superficial fractionated radiotherapy of eight fields in VI expositions, with total irradiation dose of 1400 cGy upon the following fields: right and left pectoral region, left and right shoulders, right suprascapular region, and proximal third of the right forearm. Total irradiation dose applied upon each field for the lesions located on the left and right side of the back was 1500 cGy. This therapy resulted in significant reduction of visible tumor. The patient was regularly followed up on outpatient basis for 12 months of radiotherapy, being free from local recurrence and systemic spread of the disease.

Keywords:
Primary Cutaneous Follicle Center Lymphoma; Superficial; Fractionated Radiotherapy