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Open Access Review

State-of-the-art treatment alternatives for base of skull meningiomas: complementing and controversial indications for neurosurgery, stereotactic and robotic based radiosurgery or modern fractionated radiation techniques

Stephanie E Combs1*, Ute Ganswindt4, Robert L Foote2, Douglas Kondziolka3 and Jörg-Christian Tonn5

Author Affiliations

1 Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany

2 Department of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, MN 55905, USA

3 Department of Neurosurgery, New York University, 530 First Avenue, 8R, New York, NY 10016, USA

4 Department of Radiation Oncology, Ludwigs-Maximilians-University Munich, Marchioninistraße 15, Munich, 81377, Germany

5 Department of Neurosurgery, Ludwigs-Maximilians-University Munich, Marchioninistraße 15, Munich, 81377, Germany

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Radiation Oncology 2012, 7:226  doi:10.1186/1748-717X-7-226

Published: 29 December 2012

Abstract

For skull base meningiomas, several treatment paradigms are available: Observation with serial imaging, surgical resection, stereotactic radiosurgery, radiation therapy or some combination of both. The choice depends on several factors. In this review we evaluate different treatment options, the outcome of modern irradiation techniques as well as the clinical results available, and establish recommendations for the treatment of patients with skull-base meningiomas.