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A double-blind randomised controlled trial of a natural oil-based emulsion (Moogoo Udder Cream®) containing allantoin versus aqueous cream for managing radiation-induced skin reactions in patients with cancer

Raymond Javan Chan1234*, Jacqui Keller1, Robyn Cheuk1, Rae Blades1, Lee Tripcony1 and Samantha Keogh3

Author Affiliations

1 Cancer Care Services, Royal Brisbane & Women’s Hospital, Butterfield Street, Herston, QLD, Q4029, Australia

2 School of Nursing and Midwifery, Queensland University of Technology, Kelvin Grove, QLD, Q4059, Australia

3 Research Centre for Clinical and Community Practice Innovation, Griffith University, Nathan, Q4111, Australia

4 School of Nursing and Midwifery, University of Queensland, Herston, QLD, QLD4066, Australia

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Radiation Oncology 2012, 7:121  doi:10.1186/1748-717X-7-121

Published: 31 July 2012



Radiation-induced skin reaction (RISR) is one of the most common and distressing side effects of radiotherapy in patients with cancer. It is featured with swelling, redness, itching, pain, breaks in skin, discomfort, and a burning sensation. There is a lack of convincing evidence supporting any single practice in the prevention or management of RISR.


This double-blinded randomised controlled trial aims to investigate the effects of a natural oil-based emulsion containing allantoin (as known as Moogoo Udder Cream®) versus aqueous cream in reducing RISR, improving pain, itching and quality of life in this patient group. One group will receive Moogoo Udder Cream®. Another group will receive aqueous cream. Outcome measures will be collected using patient self-administered questionnaire, interviewer administered questionnaire and clinician assessment at commencement of radiotherapy, weekly during radiotherapy, and four weeks after the completion of radiotherapy.


Despite advances of radiologic advances and supportive care, RISR are still not well managed. There is a lack of efficacious interventions in managing RISR. While anecdotal evidence suggests that Moogoo Udder Cream® may be effective in managing RISR, research is needed to substantiate this claim. This paper presents the design of a double blind randomised controlled trial that will evaluate the effects of Moogoo Udder Cream® versus aqueous cream for managing in RISR in patients with cancer.

Trial registration

ACTRN 12612000568819