Figure 7.

Model of the mechanism of action of resveratrol (RSV) and ionizing radiation (IR) to regulate cell cycle and survival in PrCa cells. A. IR induces DNA strand breaks which are detected by ATM, leading to AMPK activation and induction of the cell cycle inhibitors p53, p21^cip1 and p27^kip1. IR also activates Akt to increase protein synthesis through mTOR and stimulate cell cycle progression, proliferation and survival. B. The work presented here suggests that RSV i) enhances the effects of IR on AMPK activation, leading to an early cell cycle arrest, and ii) inhibits Akt to reduce gene expression and proliferation and enhance radiation cytotoxicity.