Table 4 |
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|
Overview of prior stereotactic radiosurgery results for the reirradiation of recurrent head and neck carcinoma. |
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|
Study |
Patients (#) |
SRS median total dose/fx |
Follow-up median, range (months) |
Tumor size median, range (cc) |
Prior irradiation Dose, median, range (Gy) |
Toxicity |
Complete Response Rate |
Overall survival |
|
|
||||||||
|
Voynov et al. [13] |
22 |
24/1-8 |
19, 11-40* |
19.1, 2.5-140.3 |
97.8, 70.1-190.3 (BED10) |
No Grade 4+ |
- |
22% at 2-yrs |
|
|
||||||||
|
Heron et al. [15] |
25 |
25-44/5 |
NS |
44.8, 4.2-217 |
66-69.2 |
No Grade 3+ |
8.6% |
18% at 1-yr |
|
|
||||||||
|
Roh et al. [14] |
36 |
30/3-5 |
17.3 |
22.6, 0.2-114.9 |
70.2, 39.6-134.4 |
No Grade 4+ 36% Grade 3 |
42.9% |
52.1% at 1-yr, 30.9% at 2-yrs |
|
|
||||||||
|
Rwigema et al. [23] |
85 |
35/1-5 |
6, 1.3-39 |
25.1, 2.5-162 |
70, 32-170.7 |
No Grade 4+ 4.7% Grade 3 |
34% |
48% at 1-yr, 16% at 2-yrs |
|
|
||||||||
|
Sulman et al. [31] |
78§ |
IMRT 60 Gy |
25, 0-81 |
64.1, 2.9-425.4 |
60, 16-75 |
20% severe Including 1% Grade 5 |
- |
58% at 2-yrs |
|
|
||||||||
|
Siddiqui et al. [25] |
44§† |
13-18/1 or 36-48/5-8 |
6.8, 1.5-48 |
15.5, 1.7-155‡ |
63.5, 50.4-74‡ |
6.7% Grade 3‡ 9% Grade 4‡ |
31% |
38.1% at 1-yr 14.3% at 2-yrs |
|
|
||||||||
|
Unger et al. [24] |
65 |
30/2-5 |
16* |
75, 7-276 |
67, 32-120 |
11% Grade 4+ |
54% |
41% at 2-yrs |
|
|
||||||||
|
Current Study |
22 (14 N-, 8 N+) |
33.7/2-5 |
24, 4-39 |
24.5, 3.4-74.4 |
40-65 |
No Grade 4+ 22.7% Grade 3 |
45.4% (N- 64.3%, N+ 12.5%) |
N- 78.6% at 2-yrs N+ 12.5% at 2-yrs |
|
|
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|
* Surviving patients † Additional non-recurrent patients treated, data presented for recurrent patients only unless otherwise noted. ‡ Includes non-recurrent patients. § Includes patients with non-squamous cell carcinomas; data presented is for combined population. |
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|
Kawaguchi et al. Radiation Oncology 2010 5:51 doi:10.1186/1748-717X-5-51 |
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