Research
Biological impact of geometric uncertainties: what margin is needed for intra-hepatic tumors?
1 Department of Radiation Oncology, Montefiore Medical Center, USA
2 Department Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan
3 Department of Radiation Oncology, University Hospital of Chung-Shan Medical University, Taiwan
4 Department of Radiologic Sciences, Thomas Jefferson University, USA
Radiation Oncology 2010, 5:48 doi:10.1186/1748-717X-5-48
Published: 3 June 2010Abstract
Background
To evaluate and compare the biological impact on different proposed margin recipes for the same geometric uncertainties for intra-hepatic tumors with different tumor cell types or clinical stages.
Method
Three different margin recipes based on tumor motion were applied to sixteen IMRT plans with a total of twenty two intra-hepatic tumors. One recipe used the full amplitude of motion measured from patients to generate margins. A second used 70% of the full amplitude of motion, while the third had no margin for motion. The biological effects of geometric uncertainty in these three situations were evaluated with Equivalent Uniform Doses (EUD) for various survival fractions at 2 Gy (SF2).
Results
There was no significant difference in the biological impact between the full motion margin and the 70% motion margin. Also, there was no significant difference between different tumor cell types. When the margin for motion was eliminated, the difference of the biological impact was significant among different cell types due to geometric uncertainties. Elimination of the motion margin requires dose escalation to compensate for the biological dose reduction due to the geometric misses during treatment.
Conclusions
Both patient-based margins of full motion and of 70% motion are sufficient to prevent serious dosimetric error. Clinical implementation of margin reduction should consider the tumor sensitivity to radiation.
