Review

Multidisciplinary approach of early breast cancer: The biology applied to radiation oncology

Céline Bourgier¹ , Mahmut Ozsahin² and David Azria³

¹  Département d'Oncologie Radiothérapie, Unité fonctionnelle de Sénologie, Institut Gustave Roussy, Villejuif, France

²  Service de Radio-Oncologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

³  Département d'Oncologie Radiothérapie, Université Montpellier I, CRLC Val d'Aurelle, Montpellier, France

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Radiation Oncology 2010, 5:2doi:10.1186/1748-717X-5-2

Published:	14 January 2010

Abstract

Early breast cancer treatment is based on a multimodality approach with the application of clinical and histological prognostic factors to determine locoregional and systemic treatments. The entire scientific community is strongly involved in the management of this disease: radiologists for screening and early diagnosis, gynecologists, surgical oncologists and radiation oncologists for locoregional treatment, pathologists and biologists for personalized characterization, genetic counselors for BRCA mutation history and medical oncologists for systemic therapies.

Recently, new biological tools have established various prognostic subsets of breast cancer and developed predictive markers for miscellaneous treatments.

The aim of this article is to highlight the contribution of biological tools in the locoregional management of early breast cancer.